Protein Details: Volume-regulated anion channel subunit LRRC8E

Function

Non-essential component of the volume-regulated anion channel (VRAC; also named VSOAC channel); an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes . The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine . Mediates efflux of amino acids; such as aspartate; in response to osmotic stress . The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2-3-cGAMP); an immune messenger produced in response to DNA virus in the cytosol . Channel activity requires LRRC8A plus at least one other family member (LRRC8B; LRRC8C; LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition . Also plays a role in lysosome homeostasis by forming functional lysosomal VRAC channels in response to low cytoplasmic ionic strength condition: lysosomal VRAC channels are necessary for the formation of large lysosome-derived vacuoles; which store and then expel excess water to maintain cytosolic water homeostasis .

Sequence

PDB Structures

Ligand Binding